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Links for GENETICS
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Biotech primer
genomics glossary http://www.genomicglossaries.com/
links to more resources: http://emice.nci.nih.gov/learning_tools/
Virtual FlyLab site
BASIC
GENETICS & how to work problems
Mitosis
& Meiosis
Art
about Genetics http://www.gene-sis.net/splash.html
Behavioral
Genetics and Ecology
Biotech
and Genome Research
Chromosomes
DNA
structure and Replication
Environmental
Genetics: Nature/Nurture
Ethics
and genes
Evolution
Karyotypes
Molecular
Genetics
Race
and genes
sex
Transcription
& Control
of Transcription
Translation
NEWS
some recommended recent
articles
http://www.nytimes.com/pages/science/life/index.html
(free registration)
http://www.sciencemag.org
(Use terminals in library or lab)
http://vector.cshl.org/News/NewsIndex.html
http://science.bio.org/
http://www.eurekalert.org/
more
Professional
Periodicals
Science Magazine (use QueensLibrary
terminals)
Proceedings of the
Nat. Acad. Sciences
Journal of Heredity (use Queens
terminals)
Journal of Medical Genetics
Genetics
Physiological
Genomics
The famous 2001 genome issues (free access and links to more stuff):
The 2002 mosquito and malaria genome issues
http://www.sciencemag.org/feature/data/mosquito/index.shtml
http://www.nature.com/nature/malaria/
(free access through Oct 2002)
Doggie genome 2003
http://www.sciencemag.org/cgi/content/full/301/5641/1854
GM focus issue:
http://www.nature.com/nrg/focus/gm/
http://www.nature.com/celldivision/library/index.html
(free papers on mitosis)
more
Other Reference materials
MOLECULAR
GENETICS
DNA tech
BASIC SOURCES, MOSTLY Mendelian
new from the NIH http://history.nih.gov/exhibits/genetics/
Basic
Review
http://vector.cshl.org/dnaftb/1/concept
choose#1Mendel's experiments
free CD http://www.roche.com/home/science/science-gengen/science-gengen-cdrom.htm
TRANSLATION
CLASSICS
- OPERON
- The lac operon http://vector.cshl.org/dnaftb/33/concept/index.html
- Terms to know: Jacob &
Monod, E. coli, lactose, b-galactosidase
(b-gal), galactose, glucose,
inducer/induction/inducible, i-gene, inhibitor (aka
repressor), operator (with binding site for inhibitor),
RNA polymerase, up/downstream, operon, negative
regulation, positive regulation, activator, cAMP, CRP (cAMP
receptor protein, aka CAP/ catabolite activator protein)
- video of Jacob: http://zygote.swarthmore.edu/gene5b.html
-
- DEVELOPMENT
- RETROVIRUSES
- Environmental
Interactions
- Obesity and Genetics: A Public Health
Perspective http://www.cdc.gov/genomics/info/perspectives/obesity.htm
- research on environmental effects on children’s health http://nationalchildrensstudy.gov/
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Genes, Abuse, and Violence
Why do some people who have
suffered physical or emotional abuse as
children display violent behavior as adults, while others do
not? According to a report by Caspi et al.
( http://www.sciencemag.org/cgi/content/short/297/5582/851
) in the 2 Aug 2002 *Science*, the answer may lie in a
complex interplay of genes and environment. The group found
that a certain form of a gene that encodes monoamine oxidase
A (MAOA), an enzyme that cleans up excess neurotransmitters
in the brain, makes men more likely to be violent -- but
only if they were abused as children.
Previous studies have shown that low levels of MAOA activity
increase aggressive behavior in both mice and humans. Caspi
et al. followed the lives of 442 males (154 of whom were
physically or sexually abused as children) living in New
Zealand for 26 years beginning from birth. Although only 12%
of the men who had been maltreated as children displayed low
MAOA activity, they accounted for 44% of the violent crimes
committed by the group. On the other hand, children who were
mistreated but had higher levels of MAOA were unlikely to
develop behavior problems as adults, a finding that suggests
that a particular MAOA genotype could protect maltreated
children against aggressive behavior. As noted by E.
Stokstad in an accompanying news story ( http://www.sciencemag.org/cgi/content/short/297/5582/752a
), the study shows how a person's genetic make up can
influence their sensitivity to social factors and the
expression of specific behaviors. (from Science
Roundup)
- more
-
- GENES & RACE
RECENT NEWS
What Huntington's disease does:
http://www.betterhumans.com/News/news.aspx?articleID=2003-09-242
&
&
http://www.biomedcentral.com/news/20031016/01
Metagenomes: sequencing the DNA of entire ecosystems to
find out which microscopic crittters are interacting with
other species.
http://www.nytimes.com/2003/10/21/science/earth/21GENE.html
Why clone a rat? http://www.wired.com/news/medtech/0,1286,60580,00.html
Ebola vaccine
http://www.chicagotribune.com/features/health/chi-0308070164aug07,1,4026278.story
(technical details; choose only if you know something about
antibodies)
http://www.biomedcentral.com/news/20030807/01
how a mutation affects brain function and
memory http://www.sciencemag.org/cgi/content/full/299/5607/639a
gene chips help make the connections between
genomics and proteonomics http://www.nytimes.com/2002/10/25/science/25CELL.html
fight cancer with a probe attached to a drug? http://news-info.wustl.edu/news/casw/taylor.html
gene for big buttox? http://newsobserver.com/news/triangle/story/1819933p-1818715c.html
it takes two helicases: http://www.eurekalert.org/pub_releases/2002-10/uoia-duf100902.php
gene for microcephaly in Amish people http://www.nih.gov/news/pr/sep2002/nhgri-30.htm
Your own genome on a CD? http://www.sfgate.com/cgi-bin/article.cgi?file=/news/archive/2002/10/02/national0612EDT0486.DTL
university gets $4.3M for corn genome research http://www.eurekalert.org/pub_releases/2002-10/rtsu-na100102.php
researcher says cancer drugs should aim at transcription
factors, not protein kinases http://www.eurekalert.org/pub_releases/2002-10/ru-wpt100102.php
ribosome research could lead to drugs for bioweapon
victims http://www.eurekalert.org/pub_releases/2002-09/danl-mmc093002.php
fragile X syndrome and diced siRNA http://www.eurekalert.org/pub_releases/2002-09/cshl-nii091702.php
A gene for brain size? http://www.nytimes.com/2002/09/24/health/genetics/24BRAI.html
lateral gene transfer evidence http://www.nature.com/nsu/020923/020923-11.html
the genetics of immunity http://www.eurekalert.org/pub_releases/2002-09/nioa-rdp092302.php
gene for embryonic heart development could help to repair
diseased hearts http://www.eurekalert.org/pub_releases/2002-09/uopm-gtr091902.php
heterozygous carriers of rare Bloom's disease are at
increased risk for cancer http://www.eurekalert.org/pub_releases/2002-09/hhmi-rdn091802.php
micro-RNAs may be controlling transcription of other genes
http://www.eurekalert.org/pub_releases/2002-09/osu-ai091702.php
a single gene, *Gp-9*, that helps control
how ants perceive pheromones and, thus, recognize queens. http://www.sciencemag.org/cgi/content/short/294/5546/1434
Spider Silk . . . from Mammalian Cells http://www.sciencemag.org/cgi/content/short/295/5554/419b
complex diseases http://www.sciencemag.org/content/vol296/issue5568/#specialintro
Genetics of Fear http://www.sciencemag.org/cgi/content/short/297/5580/400
showed that people with different versions of a
single gene have different patterns of brain activity in
response to fear. The gene -- involved in transporting
serotonin, a neurotransmitter known to modulate behavior and
emotion -- comes in two versions, or alleles: short and
long. When asked to match pictures of frightened or
angry faces, the patients with at least one short version of
the gene showed greater activity in the amygdala -- a small
structure deep in the brain that processes anxiety-related
behavior -- than people with two long copies. also see
http://www.sciencemag.org/cgi/content/short/297/5580/319a
Are we wired to cooperate? http://www.nytimes.com/2002/07/23/health/psychology/23COOP.html
The Nature vs Nurture Debate
http://www.nytimes.com/2002/09/17/science/social/17PINK.html?pagewanted=all&position=top
http://www.nytimes.com/2002/09/15/magazine/15QUESTIONS.html?ex=1033649827&ei=1&en=2089cbeeb6307244
populations living around natural radiation evolve
faster? http://news.bmn.com/news/story?day=021001&story=2
latest on cancer: http://www.sciencemag.org/cgi/content/short/297/5588/1837
;
13 Sep 2002), meanwhile, focused on the product of the gene
*BRCA2*. Mutations in that gene have been associated with
increased susceptibility to breast and ovarian cancer -- but
just why that should be the case has never been clear. In a
tour-de-force of structural biology and biochemistry, Yang
et al. provided an answer: the BRCA2 protein product, in its
normal operation, is directly involved in repairing broken
DNA by the process of homologous recombination -- in which
the intact strand of a chromosome pair is used as the
template for repair. The researchers demonstrated that the
C-terminal domain of BRCA2 c
ontains multiple DNA-binding
domains; presented in vitro evidence showing that BRCA2
interacts with another protein, RAD51, that's known to
participate in homologous recombination; and suggested that
BRCA2 helps facilitate the exchange of homologous DNA during
recombination. The findings complement a body of recent
studies showing that BRCA2 and its related gene product
BRCA1 interact with a variety of other genes that
collectively protect cells against genome instability. A
Perspective by J. H. Wilson and S. J. Elledge
( http://www.sciencemag.org/cgi/content/short/297/5588/1822
) described the study.
Gene therapy for hemophilia http://news.bmn.com/news/story?day=021001&story=1
gene chips used to track down a disease http://www.hopkinsmedicine.org/press/2002/September/020925B.htm
gene chips with live cells in culture http://news.bmn.com/news/story?day=021004&story=1
faster gene chips http://news.bmn.com/news/story?day=021003&story=1
The mosquito and the malaria genomes
mosquito genome http://www.eurekalert.org/pub_releases/2002-10/aaft-mgs092702.php
malaria genome http://www.eurekalert.org/pub_releases/2002-10/tifg-sdg093002.php
older news but still interesting
REFERENCE MATERIALS & MORE STUFF, mostly more
advanced than the minimum you have to learn
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